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Stroke in Patients with Heart Failure and Reduced Left Ventricular Ejection Fraction Neurol 54:288-294, Pullicini,P.M.,et al, 2000 See this aricle in Pubmed Article Abstract The risk of stroke increases with decreasing EF and the risk of mortality increases with the clinical severity of cardiac failure (New York Heart Association class). Data from heart failure treatment studies suggest that warfarin may reduc e stroke and mortality in patients with reduced EF, but definitive answers are lacking. The stroke rate alone is too low to be used as a primary endpoint, but an endpoint combining stroke and death (as WARCEF and WATCH propose) would allow an assessment of the effect of antithrombotics in cardiac failure. Amalgamating the data on stroke from these two trials should yield enough statistical power to compare the effects of warfarin and aspirin on stroke as an independent secondary endpoint. Whether warfa rin is superior to aspiring in reducing stroke and mortality in patients with low ejection fraction is an important clinical issue that warrants prospective evaluation.

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(click to filter results - removes previous filter) anticoagulant,treatment aspirin cerebral embolism cerebral embolism,cardiac origin cerebrovascular accident cerebrovascular accident,prevention of congestive heart failure coumarin ejection fraction ejection fraction,abnormal mortality platelet inhibiting drugs treatment of neurologic disorder

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