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Axial Parkinsonian Symptoms Can Be Improved: The Role of Levodopa and Bilateral Subthalamic Stimulation JNNP 68:595-600, Bejjani,B.P.,et al, 2000 See this aricle in Pubmed Article Abstract Improvements in totor motor disability score (62%), limb signs (62%), and axial signs (72%) obtained with STN stimulation were statistically comparable with those obtained with levodopa during the preoperative challenge (68%, 69%, and 59%, respectively). When levodopa and STN stimulation were combined there was a further improvement in total motor disability (80%) compared with preoperative levodopa administration. This consisted largely of an additional improvement in axial signs (84%) mainly for posture and postural stability, no further improvement in levodopa responsive signs being found. Axial symptoms from the ADL showed similar additional improvement when levodopa and STN stimulation were combined. These findings suggest that bilateral STN stimulation improves most axial features of Parkinson's disease and that a synergistic effect can be obtained when stimulation is used in conjunction with levodopa treatment.

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(click to filter results - removes previous filter) L-dopa Parkinson disease Parkinson disease,axial symptoms Parkinson disease,treatment of subthalamic nucleus treatment of neurologic disorder tremor,thalamic stimulation for suppression of

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