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Nontraumatic Plexitis and Heroin Addiction JAMA 225:958-961, Challenor,Y.B.,et al, 1973 See this aricle in Pubmed Article Abstract Brachial and lumbosacral plexitis were observed as new complications of intravenous injection of heroin adulterant mixtures in 13 patients (eight with brachial and five with lumbosacral plexitis). Clinical features included monoparesis with impaired sensation and hyporeflexia in the involved limb. Severe causalgia-like pain was a frequent symptom for lower extremity lesions. Electordiagnostic studies showed denervation in the weak limb, with localization of the causative lesion at a plexus rather than at a radicular or peripheral nerve level in 12 patients. One patient showed a radiular localization. The lesions appeared to be at least partially reversible. A direct toxic effect of the injectant or hypersensitivity reactions are possible causes.

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