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Warfarin-Associated Hemorrhage and Cerebral Amyloid Angiopathy
Neurol 55:947-951, Rosand,J.,et al, 2000
See this aricle in Pubmed
Article Abstract
Hemorrhages tended to be in the lobar regions of the brain, and most (76%) occurred with an international normalized ratio of = 3.0. The APOE E2 allele was overrepresented among patients with warfarin-associated lobar hemorrhage (allele f requency 0.13 versus 0.04 in control subjects; p = 0.031). After controlling for other variables associated with ICH, carriers of the E2 allele had an OR of 3.8 (95% CI, 1.0 to 14.6) for lobar ICH. CAA was pathologically diagnosed as the cause of lobar hemorrhage in 7 of 11 patients with available tissue samples. CAA is an important cause of warfarin-associated lobar ICH in the elderly. Although diagnosis of CAA before hemorrhage is not yet possible, these data offer hope that future patients at high risk for hemorrhage may be identified before initiation of warfarin therapy.
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amyloid angiopathy,cerebral
anticoagulant,complications of
apolipoprotein E
coumarin
intracerebral hemorrhage
intracerebral hemorrhage,lobar
leuko-araiosis
risk factors
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