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Antibodies to glutamic acid decarboxylase (GAD-Ab) are described in patients with insulin-dependent (type 1) diabetes mellitus (IDDM), in stiff-man syndrome, and, recently, in a few patients with cerebellar ataxia. These results suggest a l ink between high level of GAD-Ab and some cases of cerebellar ataxia, particularly women with IDDM. If high serum levels of GAD-Ab are detected, the cerebrospinal fluid should be evaluated for the presence of oligoclonal IgG bands and intrathecal synthes is of GAD-Ab to further prove an autoimmune origin of the syndrome. |
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ataxia ataxia,cerebellar ataxic gait autoimmune cerebellar ataxia autoimmune disease cerebellar ataxia,primary cerebellar atrophy,primary cerebrospinal fluid,abnormal cerebrospinal fluid,oligoclonal IgG in diabetes mellitus dysarthria glutamic acid decarboxylase,antibody MRI MRI,abnormal MRI,negative nystagmus
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