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Pathological Correlates of Late-Onset Dementia in a Multicentre, Community-based Population in England and Wales Lancet 357:169-175, Neuroapthology Group of the Medical Research Counc, 2001 See this aricle in Pubmed Article Abstract Alzheimer-type and vascular pathology were the major pathological correlates of cognitive decline in this elderly sample, as expected, but most patients had mixed disease. There were no clear thresholds of these features that predicted deme ntia status. The findings therefore challenge conventional dementia diagnostic criteria in this setting. Additional factors must determine whether moderate burdens of cerebral Alzheimer-type pathology and vascular lesions are associated with cognitive f ailure.

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(click to filter results - removes previous filter) Alzheimer's disease dementia dementia,cerebrovascular disease causing neuropathology neuropathology,brain old age,neurology of

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