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PH and SICH but not HI were associated with rtPA. Also, PH and SICH but no HI were more severe in rtPA-treated patients than in those receiving placebo. Risk factors for PH were rtPA, extent of parenchymal hypoattenuation on baseline CT, c ongestive heart failure, increasing age, and baseline systolic blood pressure. The risk of PH on rtPA was increased in older patients and in those who were treated with aspirin before thrombolysis. Risk factors for SICH were rtPA, congestive heart failu re, extent of parenchymal hypoattenuation, and increasing age. The risk of SICH on rtPA was increased in patients who were treated with aspirin before thrombolysis. This secondary analysis of ECASS II has confirmed the importance of the extent of hypoat tenuation as a risk factor for severe HT. The findings also suggest that older patients and those who have used aspirin before stroke are at a higher risk of a severe HT on rtPA. |
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adverse drug reaction aspirin CAT scan CAT scan,abnormal cerebral infarction,hemorrhagic cerebrovascular accident,thrombolytic agents in treatment fibrinolytic agents fibrinolytic agents,complications intracerebral hemorrhage old age,neurology of risk factors tissue plasminogen activator,intravenous
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