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A Longitudinal MRI Study of Histopathologically Defined Hypointense Multiple Sclerosis Lesions Ann Neurol 49:793-796, Bitsch,A.,et al, 2001 See this aricle in Pubmed Article Abstract Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsi ed MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.

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