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In the first 6 months, fewer new enhancing lesions occurred in the IFNB-1b arm. This difference was greater for small (70% decrease) than for large (46% decrease) lesions. Hypointense T1 lesions were more likely to form from large (25%) th an from small (9%) enhancing lesions in both treatment arms. Patients taking IFNB-1b developed fewer hypointense T1 lesions; however, the proportion of enhancing lesions developing into hypointense T1 lesions was similar in both arms. IFNB-1b reduced th e number of new enhancing lesions, with a greater effect on small lesions. However, when a new enhancing lesion did become established, treatment with IFNB-1b did not alter its subsequent course. |
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interferon
interferon beta 1-b
MRI,contrast enhanced
MRI,demyelinating disease
MRI,serial
multiple sclerosis
multiple sclerosis,secondary progressive
multiple sclerosis,treatment of
treatment of neurologic disorder
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