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Severe Neurologic Complications After Hematopoietic Stem Cell Transplantation in Children
Neurol 59:1895-1904,E13, Farci,M.,et al, 2002
See this aricle in Pubmed

Article Abstract
Thirty-seven children (13.6%) developed SNE after a median of 90 days (range, 5 days to 8.8 years) after HSCT. Cyclosporine A (CSA) neurotoxicity was the most frequent SNE (n = 21), followed by irradiation or chemotherapy injury (n = 7), CN S infection (n = 7), cerebrovascular events (n = 3), and immune-mediated etiology SNE (n = 2). Eleven patients (30%) died because of the neurologic complications. Type of HSCT, treatment with total body irradiation (TBI), acute graft-vs-host disease (Gv HD), GvHD >grade 2, and treatment with CSA were associated with a significant increased risk of SNE. Severe neurologic complications are frequent (14%) among children receiving HSCT, causing 8.5% of deaths after transplant. Transplant from allogeneic do nor, especially if unrelated, the development of severe acute GvHD grade >2, and the use of TBI in the preparative regimen are the main risk factors for such complications.
 
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cataracts
central nervous system,infection of
chemotherapy,CNS treatment and complications with
children
chronic graft versus host disease
cyclosporine
iatrogenic neurologic disorders
immunosuppressive agents
intracerebral hemorrhage
leukoencephalopathy
mortality
MRI
MRI,abnormal
neurotoxic
opportunistic infection
opportunistic infection,CNS
peripheral blood stem cell transplantation
radiation therapy,CNS treatment and complications with
radiation therapy,total body
stem cell transplantation

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