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Neuronal Loss Is Greater in the Locus Coeruleus Than Nucleus Basalis and Substantia Nigra in Alzheimer and Parkinson Diseases
Arch Neurol 60:337-341, 320, Zarow,C.,et al, 2003
See this aricle in Pubmed

Article Abstract
For both Alzheimer Disease (AD) and Parkinson disease (PD) the greatest neuronal loss was found in the locus coeruleus (LC). In AD, neuronal loss was most severe and best correlated with the duration of illness in the LC, rather than in nucle us basalis (NB) as traditionally expected. Correlations between neuronal loss in the LC and NB (but not SN) in both PD and AD suggest that the former 2 nuclei may share common pathogenetic susceptibilities. Given the prominent loss of neurons in the LC, d etection and treatment of noradrenergic deficiencies warrant attention in both AD and PD.
 
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Alzheimer's disease
locus ceruleus,lesion of
neuronal degeneration
neuronal loss
neuropathology
neuropathology,brain
nucleus basalis of Meynert
Parkinson disease
substantia nigra

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