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High- and Low-Risk Profiles for the Development of Multiple Sclerosis Within 10 Years After Optic Neuritis Arch Ophthalmol 121:944-949, Optic Neuritis Study Group, 2003 See this aricle in Pubmed Article Abstract The 10-year risk of multiple sclerosis following an initial episode of acute optic neuritis significantly higher if there is a single brain MRI lesion; higher numbers of lesions do not appreciably increase that risk. However, even when brain lesions are seen on MRI, more than 40% of the patients did not develop clinical multiple sclerosis after 10 years. In the absence of MRI lesions, certain demographic and clinical features seem to predict a very low likelihood of developing multiple sclerosis. This natural history information is a critical input for estimating a patientÆs 10-year multiple sclerosis risk and for weighing the benefit of initiating prophylactic treatment at the time of optic neuritis or other initial demyelinating events in the central nervous system.

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(click to filter results - removes previous filter) MRI MRI,abnormal multiple sclerosis multiple sclerosis,prophylaxsis multiple sclerosis,risk factors for multiple sclerosis,treatment of multiple sclerosis,treatment of,first attack optic neuritis review article risk factors

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