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Neurotoxocity of Intrathecal Methotrexate: MR Imaging Findings AJNR 24:1887-1890, Sandoval,C.,et al, 2003 See this aricle in Pubmed Article Abstract We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation. Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restricted diffusion. We attribute the clinical and radiographic findings to cytotoxic edema secondaryto intrathecal methotrexate.

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(click to filter results - removes previous filter) adverse drug reaction cerebral edema cerebral edema,cytotoxic chemotherapy,CNS treatment and complications with intrathecal chemotherapy methotrexate MRI MRI,abnormal MRI,diffusion weighted neurotoxic

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