Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Effects of Cholesterol-lowering with Simvastatin on Stroke and Other Major Vascular Events in 20 536 People with Cerebrovascular Disease or Other High-Risk Conditions
Lancet 363:757-767, Heart Protection Study Collaborative Group, 2004
See this aricle in Pubmed

Article Abstract
Much larger numbers of people in the present study suffered a stroke than in any previous cholesterol-lowering trial. The results demonstrate that statin therapy rapidly reduces the incidence not only of coronary events but also of ischaemic strokes, with no apparent effect on cerebral haemorrhage, even among individuals who do not have high cholesterol concentrations. Allocation to 40 mg simvastatin daily reduced the rate of ischaemic strokes by about one-quarter and so, after making allowance for non-compliance in the trial, actual use of this regimen would probably reduce the stroke rate by about a third. HPS also provides definite evidence that statin therapy is beneficial for people with pre-existing cerebrovascular disease, even if they do not already have manifest coronary disease.
 
Related Tags
(click to filter results - removes previous filter)

cerebrovascular accident
cerebrovascular accident,prevention of
cholesterol
cholesterol,LDL
prevention of neurologic disorders
simvastatin
statin therapy
treatment of neurologic disorder

Click Here to return To Results