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Mirtazapine is Effective in the Prophylactic Treatment of Chronic Tension-Type Headache Neurol 62:1706-1711, Bendtsen,L. &Jensen,R., 2004 See this aricle in Pubmed Article Abstract Mirtazapine reduced AUC by 34% more than placebo in difficult-to-treat patients. This finding is clinically relevant and may stimulate the development of prophylactic treatments with increased efficacy and fewer side effects for tension-type headache and other types of chronic pain.

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