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Selective Vulnerability in the Developing Central Nervous System Pediatr Neurol 30:227-235, McQuillen,P.S. &Ferriero,D.M., 2004 See this aricle in Pubmed Article Abstract Selective patterns of cerebral injury are observed after a variety of insults at different ages during development. Distinct populations of cells demonstrate selective vulnerability during these specific developmental stages, which may account for the observed patterns of injury. We review the evidence that injury to preoligodendrocytes and subplate neurons contributes to periventricular white matter injury in preterm infants, whereas thalamic neuronal cell vulnerability and neuronal nitric oxide synthase-expressing striatal inter-neurons resistance resulting deep gray nuclei damage in the term infant. The unique roles of particular mechanisms including oxidative stress, glutamatergic neurotransmission, and programmed cell death are discussed in the context of this selective vulnerability.

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(click to filter results - removes previous filter) deep gray nuclei infant,evaluation of newborn,evaluation of oxidative stress premature infant review article selective vulnerability term infant white matter disease white matter disease,periventricular

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