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Levodopa and the Progression of Parkinson's Disease
NEJM 351:2498-2508, The Parkinson Study Group, 2004
See this aricle in Pubmed

Article Abstract
The clinical data suggest that levodopa either slows the progression of ParkinsonÆs disease or has a prolonged effect on the symptoms of the disease. In contrast, the neuro-imaging data suggest either that levodopa accelerates the loss of nigrostriatal dopamine nerve terminals or that its pharmacologic effects modify the dopamine transporter. The potential long-term effects of levodopa on ParkinsonÆs disease remain uncertain.
 
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adverse drug reaction
controversies in neurology
L-dopa
L-dopa,drug interactions with and side effects of
neuronal degeneration
nigrostriatal pathway
Parkinson disease
Parkinson disease,treatment of
sinemet
single photon emission computed tomography
treatment of neurologic disorder

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