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Dementia Following Treatment of Brain Tumors with Radiotherapy Administered Alone or in Combination with Nitrosourea-Based Chemotherapy: A Clinical and Pathological Study J Neurooncol 41:137-149, Vigliani,M.C.,et al, 1999 See this aricle in Pubmed Article Abstract The clinical picture consisted of a progressive subcortical dementia occurring 3-12 months after a course of cerebral radiotherapy. Examination revealed early bilasteral corticospinal tract involvement in all patients and dopa-resistnat Parkinsonian syndrome in two. On CT scan and MRI of the brain, the main features consisted of progressive enlargement of the ventricles associated with a diffuse hypodensity/hyperintensity of the white matter best seen on T2 weighted images on MRI. The course was progressive over 8-48 months in 3 patients while one patient had stabilization of his condition for about 28 years. Treatment with corticosteroids or shunting did not produced sustained improvement and all patients eventually died. Pathological examination revealed diffuse white matter pallor with sparing of the arcuate fibers in all patients.

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(click to filter results - removes previous filter) chemotherapy,CNS treatment and complications with dementia iatrogenic neurologic disorders leukoencephalopathy MRI MRI,abnormal neoplasm,primary intracerebral neoplasm,primary of CNS neoplasm,primary of CNS-treatment of nitrosourea Parkinsonism syndrome radiation therapy,CNS treatment and complications with white matter disease

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