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Acute Encephalopathy Associated with Intravenous Immunoglobulin Therapy AJNR 26:2311-2315, Wada,A.,et al, 2005 See this aricle in Pubmed Article Abstract We report a rare case of acute encephalopathy following intravenous immunoglobulin therapy for human herpes virus 6 infection in a child. MR imaging findings suggest that the dominant causative mechanism of acute encephalopathy is cytotoxic edema, and the findings indicate 2 primary mechanisms. Reversibility of the restriction of water diffusion (low apparent diffusion coefficient value) on diffusion-weighted MR imaging suggests intramyelinic edema in the myelin sheath, and an increase of glutamate and glutamine complex peak on MR spectroscopy suggests excitotoxic injury to the neurons and astrocytes.

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(click to filter results - removes previous filter) adverse drug reaction encephalopathy gammaglobulin therapy,intravenous leukoencephalopathy MRI MRI,abnormal MRI,diffusion weighted MRS white matter disease

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