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Valproic Acid Adjunctive Therapy for HIV-Associated Cognitive Impairment: A First Report
Neurol 66:919-921, Schifitto,G.,et al, 2006
See this aricle in Pubmed

Article Abstract
In vitro and animal model data demonstrate that valproic acid (VPA) can ameliorate HIV-associated neurotoxicity. The authors conducted a pilot 10-week placebo-controlled study of VPA 250 mg twice daily in 22 HIV-infected individuals with (n = 16) and without (n = 6) cognitive impairment. VPA was safe and well tolerated, with trends toward improved neuropsychological performance and brain metabolism in the impaired subjects.
 
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acquired immunodeficiency syndrome dementia complex
cognition
dementia
human immunodeficiency virus type 1
psychological testing
sodium valproate
treatment of neurologic disorder

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