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Significance of T2 Lesions in Multiple Sclerosis: A 13-Year Longitudinal Study Ann Neurol 60:236-242, Rudick,R.A.,et al, 2006 See this aricle in Pubmed Article Abstract T2 lesions in relapsing-remitting MS correlate strongly with brain tissue loss and brain tissue integrity 13 years later, and with clinical disease severity, though age significantly impacts the clinical correlation. The results provide direct evidence for the disability threshold hypothesis in MS and support monitoring T2 lesions in relapsing-remitting MS.

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