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This case of transfusion-associated vCJD infection, identified ante-mortem, is the third instance from a group of 23 known recipients who survived at least 5 years after receiving a transfusion from donors who subsequently developed vCJD. The risk to the remaining recipients of such transfusions is probably high, and these patients should be offered specialist follow-up and investigation. Tonsil biopsy will allow early and pre-symptomatic diagnosis in other iatrogenically exposed individuals at high risk, as in those with primary infection with bovine spongiform encephalopathy prions. |
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asymptomatic
blood transfusion
central nervous system,infection of
concentration,impaired
dementia
iatrogenic neurologic disorders
imbalance
immunohistochemistry
Jakob-Creutzfeldt disease
Jakob-Creutzfeldt disease,variant
memory,impairment of
MRI,abnormal
MRI,false negative
MRI,negative
neurologic disease,diagnoses of
neuropathology
pain,leg
preclinical
prion disease
pulvinar sign
risk factors
thalamus,lesion of
thalamus,lesion of-bilateral
tonsil biopsy
walking,difficulty with
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