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This case of transfusion-associated vCJD infection, identified ante-mortem, is the third instance from a group of 23 known recipients who survived at least 5 years after receiving a transfusion from donors who subsequently developed vCJD. The risk to the remaining recipients of such transfusions is probably high, and these patients should be offered specialist follow-up and investigation. Tonsil biopsy will allow early and pre-symptomatic diagnosis in other iatrogenically exposed individuals at high risk, as in those with primary infection with bovine spongiform encephalopathy prions. |
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asymptomatic blood transfusion central nervous system,infection of concentration,impaired dementia iatrogenic neurologic disorders imbalance immunohistochemistry Jakob-Creutzfeldt disease Jakob-Creutzfeldt disease,variant memory,impairment of MRI,abnormal MRI,false negative MRI,negative neurologic disease,diagnoses of neuropathology pain,leg preclinical prion disease pulvinar sign risk factors thalamus,lesion of thalamus,lesion of-bilateral tonsil biopsy walking,difficulty with
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