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Effect of Sedation With Dexmedetomidine vs Lorazepam on Acute Brain Dysfunction in Mechanically Ventilated Patients: The MENDS Randomized Controlled Trial
JAMA 298:2644, Pandharipande,P.P., 2007
See this aricle in Pubmed

Article Abstract
In mechanically ventilated ICU patients managed with individualized targeted sedation, use of a dexmedetomidine infusion resulted in more days alive without delirium or coma and more time at the targeted level of sedation than with a lorazepam infusion.
 
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benzodiazepine
coma
critical care unit
delirium
dexmedetomidine
lorazepam
respirator
sedation
treatment of neurologic disorder

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