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The Varicella Zoster Virus Vasculopathies: Clinical, CSF, Imaging, and Virologic Features Neurol 70:853-860, Nagel,M.A.,et al, 2008 See this aricle in Pubmed Article Abstract Rash or CSF pleocytosis is not required to diagnose varicella zoster virus (VZV) vasculopathy, whereas MRI/CT abnormalities are seen in almost all patients. Most patients had mixed large and small artery involvement. Detection of anti-VZV IgG antibody in CSF was a more sensitive indicator of VZV vasculopathy than detection of VZV DNA (p < 0.001). Determination of optimal antiviral treatment and benefit of concurrent steroid therapy awaits studies with larger case numbers.

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