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Thrombolysis with Alteplase 3-4.5 h After Ischaemic Stroke (SITS-ISTR): An Observational Study Lancet 372:1303-1309, Wahlgren,N.,et al, 2008 See this aricle in Pubmed Article Abstract Alteplase remains safe when given at 3-4.5 h after ischaemic stroke, offering an opportunity for patients who cannot be treated within the standard 3-h timeframe.

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