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Neurologic Manifestations of Localized Scleroderma: A Case Report and Literature Review
Neurol 71:1538-1545, Kister,I.,et al, 2008
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Article Abstract
We describe a young woman with localized scleroderma, seizures, numerous persistently enhancing white matter lesions on brain MRI, and oligoclonal bands in the CSF. The case is remarkable in the widespread bilateral distribution of the lesions and their enhancement during more than a year of follow-up despite immunosuppression. Literature search yielded 54 case descriptions of localized scleroderma associated with neurologic symptoms and neuroimaging findings. All patients had craniofacial scleroderma: linear scleroderma en coup de sabre (LScs), progressive facial hemiatrophy (PFH, or Parry-Romberg syndrome) or both. LScs and PFH should be viewed as variants of craniofacial localized scleroderma as they often manifest in the same patient, share the same neurologic manifestation and imaging features, and evidence pathologic inflammation in skin and CNS.
 
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cerebrospinal fluid,oligoclonal IgG in
headache
hemifacial atrophy
MRI
MRI,abnormal
MRI,contrast enhanced
multiple sclerosis,differential diagnosis of
neurologic examination
neurologic signs
neurologic symptoms
progressive hemifacial atrophy
review article
scleroderma
scleroderma,neurologic involvement with
seizure
skin,lesions in neurologic disorders

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