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Amyloid deposition can be identified among cognitively normal elderly persons during life, and the prevalence of asymptomatic amyloid deposition may be similar to that of symptomatic amyloid deposition. In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significant amyloid burden can remain cognitively normal. However, this finding is based on relatively small numbers and needs to be replicated in larger cohorts. Longitudinal follow-up of these subjects will be required to support the potential of PiB imaging to identify preclinical Alzheimer disease, or, alternatively, to show that amyloid deposition is not sufficient to cause Alzheimer disease within some specified period. |
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Alzheimer's disease
Alzheimer's disease,preclinical
amyloid
amyloid plaques
asymptomatic
CAT scan,emission
CAT scan,emission,abnormal
cognition
dementia
mild cognitive impairment
normal
old age,neurology of
Pittsburgh Compound B
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