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Effect of Clopidogrel Added to Aspirin in Patients with Atrial Fibrillation NEJM 360:2066-2078,2127, The ACTIVE Investigators, 2009 See this aricle in Pubmed Article Abstract In patients with atrial fibrillation for whom vitamin K-antagonist therapy was unsuitable, the addition of clopidogrel to aspiring reduced the risk of major vascular events, especially stroke, and increased the risk of major hemorrhage.

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