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The Spectrum of Mutations in Progranulin: A Collaborative Study Screening 545 Cases of Neurodegeneration
Arch Neurol 67:161-170,145, Yu,C.-E.,et al, 2010
See this aricle in Pubmed
Article Abstract
Pathogenic mutations were found only in FTD-spectrum cases and not in other related neurodegenerative diseases. Haploinsufficiency of GRN is the predominant mechanism leading to FTD.
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amyotrophic lateral sclerosis
degenerative diseases of CNS
dementia
dementia,frontotemporal
gene mutation
lobar atrophy
Parkinsonism syndrome
progranulin
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