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Overall, the phenotype associated with the novel neuropil antibodies includes dominant behavioural and psychiatric symptoms and seizures that often interfere with the evaluation of cognition and memory, and brain MRI or FDG-PET abnormalities less frequently restricted to the medial temporal lobes than in patients with classical paraneoplastic or VGKC antibodies. When compared with patients with VGKC antibodies, patients with these novel antibodies are more likely to have CSF inflammatory abnormalities and systemic tumours (teratoma and thymoma), and they do not develop SIADH-like hyponatraemia. Although most autoantigens await characterization, all share intense expression by the neuropil of hippocampus, with patterns of immune-labelling characteristic enough to suggest the diagnosis of these disorders and predict response to treatment. |
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autoantibodies
CAT scan,emission,abnormal
glutamic acid decarboxylase,antibody
limbic encephalitis
mesial temporal lobe
MRI,abnormal
novel cell-membrane antigens
seizure
treatment of neurologic disorder
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