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Open Biopsy in Patients With Acute Progressive Neurologic Decline and Absence of Mass Lesion Neurol 75:419-424, Schuette,A.J., et al, 2010 See this aricle in Pubmed Article Abstract In patients with progressive neurologic decline without a radiographic mass lesion or immunodeficiency, open brain biopsy often fails to provide a diagnosis and even more rarely does it significantly alter treatment.

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