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Neuroimaging in CLD is striking and is an important tool in diagnosing CLD. Extensive white matter involvement as well as involvement of the globus pallidus and patchy involvement of the thalami and substantia nigra are characteristic. MRS findings are compatible with destruction of normal brain parenchyma with evidence of anaerobic metabolism in the regions of demyelination. Clinical suspicion of VWM in a Native American infant from this region should prompt the consideration of CLD with appropriate imaging work-up and genetic testing. |
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basal ganglia,lesion of CAT scan,abnormal children Cree leukoencephalopathy genetic testing globus pallidus,lesion of globus pallidus,lesion of,bilateral leukoencephalopathy mortality MRI MRI,abnormal MRI,CAT scan compared to MRI,diffusion weighted MRS Native Americans neuropathology substantia nigra symmetric brain lesions thalamus,lesion of thalamus,lesion of-bilateral white matter disease
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