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Fatal PML Associated with Efalizumab Therapy
Neurol 78:458-467, Schwab,N.,et al, 2012
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Article Abstract
From these data we propose that inhibition of peripheral and intrathecal T-cell activation and suppression of CNS effector-phase migration both characterize efalizumab-associated PML. LFA-1 may be a crucial factor in homeostatic JC virus control.
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complications
efalizumab
iatrogenic neurologic disorders
monoclonal antibodies
mortality
progressive multifocal leucoencephalopathy
psoriasis
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