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Closure or Medical Therapy for Cryptogenic Stroke with Patent Foramen Ovale NEJM 366:991-999,1048, Furlan,A.J.,et al, 2012 See this aricle in Pubmed Article Abstract In patients with cryptogenic stroke or TIA who had a patent foramen ovale, closure with a device did not offer a greater benefit than medical therapy alone for the prevention of recurrent stroke or TIA.

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