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Clinical and Radiological Characteristics of Methotrexate-Induced Acute Encephalopathy in Pediatric Patients with Cancer
Ann Oncol 19:178-184, Inaba, H.,et al, 2008
See this aricle in Pubmed

Article Abstract
Acute MTX toxicity often manifests as fluctuating neurologic symptoms with alternating hemispheric involvement. Restricted diffusion on DWI is a reliable early sign of acute MTX encephalopathy and resolves as clinical status improves, despite the persistence of subtle abnormalities on MRI.
 
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adverse drug reaction
alternating hemiplegia
alternating hemiplegia of childhood
aphasia
chemotherapy,CNS treatment and complications with
children
choreoathetosis
complications
dysphasia
encephalopathy
encephalopathy,acute
headache
hemiplegia
iatrogenic neurologic disorders
leukoencephalopathy
methotrexate
movement disorder
MRI,abnormal
MRI,diffusion weighted
white matter disease

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