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Clinical and Biomarker Changes in Dominantly Inherited Alzheimers Disease NEJM 367:795-804,864, Bateman, R.J.,et al, 2012 See this aricle in Pubmed Article Abstract We found that autosomal dominant Alzheimer?s disease was associated with a series of pathophysiological changes over decades in CSF biochemical markers of Alzheimer?s disease, brain amyloid deposition, and brain metabolism as well as progressive cognitive impairment. Our results require confirmation with the use of longitudinal data and may not apply to patients with sporadic Alzheimer?s disease.

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