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In children with congenital rubella infection the deficits remain stable; neurologic deterioration after the first years of life is not believed to occur. We have encountered three patients with a definite or presumed diagnosis of congenital rubella, in whom a progressive neurologic illness deveoped that began in the second decade and was characterized by spasticity, ataxia, intellectual deterioration, and seizures.High antibodiy titers to rubella virus in serum and spinal fluid were present in two, and all had increased cerebrospinal-fluid protein and gamma globulin. Extensive attemps to recover a virus from brain and body fluids were unsuccessful. The brains of two patients showed a widespread, progressive, subacute panencephalitis mainly affecting white matter. These data suggest that rubella virus may be a cause of progressive panencephalitis. |
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cerebrospinal fluid,elevated protein of cerebrospinal fluid,gammaglobulin of cerebrospinal fluid,oligoclonal IgG in children congenital infection,CNS congenital infection,viral encephalitis encephalitis,viral gait disorder intellectual deterioration intrauterine infection intrauterine infection,viral intrauterine infection,viral of CNS neuropathology pleocytosis of cerebrospinal fluid progressive neurologic disorder rubella encephalitis,progressive rubella syndrome rubella virus serologic testing serologic testing of cerebrospinal fluid slow virus infection of CNS viral infection virus,slow white matter disease
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