Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Subacute Sclerosing Panencephalitis
Postgrad Med J 78:63-70, Garg, R.K.,et al, 2002
See this aricle in Pubmed

Article Abstract
Subacute sclerosing panencephalitis (SSPE) is a progressive neurological disorder of childhood and early adolescence. It is caused by persistent defective measles virus. Brain biopsies or postmortem histopathological examination show evidence of astrogliosis, neuronal loss, degeneration of dendrites, demyelination, neurofibrillary tangles, and infiltration of inflammatory cells. Patients usually have behavioral changes, myoclonus, dementia, visual disturbances, and pyramidal and extrapyramidal signs. The disease has a gradual progressive course leading to death within 1-3 years. The diagnosis is based upon characteristic clinical manifestations, the presence of characteristic periodic EEG discharges, and demonstration of raised antibody titre against measles in the plasma and cerebrospinal fluid. Treatment for SSPE is still undetermined. A combination of oral Isoprinosine (Inosiplex) and intraventricular interferon alfa appears to be the best effective treatment. Patients responding to treatment need to receive it life long. Effective immunization against measles is the only solution presently available to the problem of this dreaded disease.
 
Related Tags
(click to filter results - removes previous filter)

antibodies to measles
brain biopsy
brainstem,lesion of
cerebral cortex
cerebral cortical atrophy
children
coma
cortical blindness
deep gray nuclei
dementia
diagnostic criteria
electroencephalogram,abnormalities of
electroencephalogram,periodic complexes
encephalitis
gray matter
inclusion bodies
inclusion bodies,eosinophilic cytoplasmic
inclusion bodies,eosinophilic intranuclear
intellectual deterioration
mortality
MRI,abnormal
myoclonus
neurologic disease,diagnoses of
persistent vegetative state
personality change
polymerase chain reaction
prognosis
progressive neurologic disorder
review article
rubeola virus
seizure
serologic testing
slow virus infection of CNS
subacute sclerosing panencephalitis(S.S.P.E.)Dawson's disease
treatment of neurologic disorder
viral infection
viral infection,CNS
virus,slow
white matter disease
white matter disease,subcortical

Click Here to return To Results