Neurology Specific Literature Search   
 
[home][thesaurus]
    
Click Here to return To Results

 

Subacute sclerosing panencephalitis: An Update
Dev Med Child Neurol 52:901-907, Guitierrez, J.,et al, 2010
See this aricle in Pubmed

Article Abstract
Subacute sclerosing panencephalitis (SSPE) is a chronic encephalitis occurring after infection with measles virus. The prevalence of the disease varies depending on uptake of measles vaccination, with the virus disproportionally affecting regions with low vaccination rates. The physiopathology of the disease is not fully understood; however, there is evidence that it involves factors that favour humoral over cellular immune response against the virus. As a result, the virus is able to infect the neurons and to survive in a latent form for years. The clinical manifestations occur, on average, 6 years after measles virus infection. The onset of SSPE is insidious, and psychiatric manifestations are prominent. Subsequently, myoclonic seizures usually lead to a final stage of akinetic mutism. The diagnosis is clinical, supported by periodic complexes on electroencephalography, brain imaging suggestive of demyelination, and immunological evidence of measles infection. Management of the disease includes seizure control and avoidance of secondary complications associated with the progressive disability. Trials of treatment with interferon, ribavirin, and Isoprinosine using different methodologies have reported beneficial results. However, the disease shows relentless progression; only 5% of individuals with SSPE undergo spontaneous remission, with the remaining 95% dying within 5 years of diagnosis.
 
Related Tags
(click to filter results - removes previous filter)

akinetic mute
atypical
coma
diagnostic criteria
differential diagnosis
electroencephalogram,abnormalities of
electroencephalogram,periodic complexes
intellectual deterioration
mimics
mortality
MRI,abnormal
myoclonus
neurologic disease,diagnoses of
pleocytosis of cerebrospinal fluid
prognosis
progressive neurologic disorder
psychiatric problems in neurologic disorders
review article
rubeola virus
seizure
subacute sclerosing panencephalitis(S.S.P.E.)Dawson's disease
treatment of neurologic disorder
viral infection
viral infection,CNS
visuospatial disturbance
white matter disease

Click Here to return To Results