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Statins can cause a spectrum of muscle diseases, most of which are self-limited and improve with discontinuation of the offending agent. In a subgroup, an autoimmune necrotizing myopathy develops that persists after discontinuation of statins. Specific autoantibody testing can help identify these patients in clinical practice and determine the need for Immunosuppressive therapy. |
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adverse drug reaction anti HMGCR antibody autoimmune disease complications creatine phosphokinase(CPK)elevated immunosuppressive agents muscle biopsy muscle pain muscle weakness myopathy,drug-induced myopathy,necrotizing myopathy,necrotizing,autoimmune myopathy,steroid responsive myopathy,toxic myositis prognosis risk factors statin therapy statin therapy,discontinuation treatment of neurologic disorder weakness weakness,proximal
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