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The staged pattern of globus pallidus infarcts in isolated methylmalonic academia suggests a nonuniform, regionally specific cellular susceptibility to metabolic injury, even for patients having milder biochemical phenotypes. In support of this hypothesis, the delineation of lacunar infarcts in the pars reticulate of the substantia nigra, a tissue functionally and histologically identical to the globus pallidus interna, supports the concept of cell-specific pathology. |
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basal ganglia,lesion of
brainstem,lesion of
CAT scan,abnormal
cerebral infarction
cerebrovascular accident
children
deep gray nuclei
globus pallidus,infarction
globus pallidus,lesion of
globus pallidus,lesion of,bilateral
inborn errors of metabolism
metabolic disorder,primary
methylmalonic acidemia
midbrain,infarction of
midbrain,lesion of
MRI,abnormal
substantia nigra
symmetric brain lesions
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