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Brain Abnormalities in Newly Diagnosed Neuropsychiatric Lupus: Systematic MRI Approach and Correlation with Clinical and Laboratory Data in a Large Multicenter Cohort
Autoimmun Rev 14:153-159, Sarbu, N.,et al, 2015
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Article Abstract
We included 108 patients (mean 40.6 � 14.2 years; range 14-77), 91.7% women. The most frequent syndromes were headache (28.5%), cerebrovascular disease (15.5%), and cognitive dysfunction (11.4%). Brain abnormalities were found in 59.3%. SVD was the most common (55.6%), followed by LVD (13%) and inflammatory-like lesions (6.5%). The most frequent SVD findings were WMH (53.7%), atrophy (18.5%), microbleeds (13.7%) and lacunes (11.1%). Cerebrovascular syndrome correlated with LVD (p=0.001) and microbleeds (p=0.002), cognitive dysfunction with WMH (p=0.045) and myelopathy with inflammatory-like lesions (p=0.020). Low C4 and CH50 correlated with inflammatory-like lesions (p�0.001, 9=0.019) and lupus anticoagulant with WMH (p=0.018), microbleeds (p=0.002) and atrophy (p=0.008). Vascular disease is the hallmark of NPSLE. Certain syndromes and immunological patterns are prone to more extensive brain damage. MRI could provide significant clinical information and insights into the pathological substrate.
 
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brain atrophy
cerebral infarction,subcortical
cerebrovascular accident
cognition
dementia
headache
lacunar infarction
lupus anticoagulant
meningitis,aseptic
meningitis,noninfectious
microhemorrhage,intracerebral
MRI,abnormal
MRI,contrast enhanced
MRI,negative
myelopathy
pleocytosis of cerebrospinal fluid
psychosis
seizure
small vessel disease
systemic lupus erythematosus
systemic lupus erythematosus,neurologic complications with
white matter disease

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