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Non-Alzheimers Dementia 1 Frontotemporal Dementia Lancet 386:1672-1682, Bang, Jee.,et al, 2015 See this aricle in Pubmed Article Abstract Frontotemporal dementia is an umbrella clinical term that encompasses a group of neurodegenerative diseases characterized by progressive deficits in behavior, executive function, or language. Frontotemporal dementia is a common type of dementia, particularly in patients younger than 65 years. The disease can mimic many psychiatric disorders because of the prominent behavioural features. Various underlying neuropathological entities lead to the frontotemporal dementia clinical phenotype, all of which are characterized by the selective degeneration of the frontal and temporal cortices. Genetics is an important risk factor for frontotemporal dementia. Advances in clinical, imaging, and molecular characterization have increased the accuracy of frontotemporal dementia diagnosis, thus allowing for the accurate differentiation of these symptoms from psychiatric disorders. As the understanding of the molecular basis for frontotemporal dementia improves, rational therapies are beginning to emerge.

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