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Meningitis caused by Candida albicans is a very infrequent entity. We present 3 intravenous drug users with chronic neutrophilic meningitis caused by Candida albicans. The clinical, microbiological and radiological features of the 3 patients are reviewed. The interval between the onset of the disease and the diagnosis was long (from 4 to 12 months). Candida albicans was cultured from cerebrospinal fluid (CSF) in the 3 patients. All of them developed hydrocephalus, meanwhile arachnoiditis was disclosed in two. The therapy with amphotericin, 5-flucytosine and fluconazole produced clinical improvement and the sterilization of the CSF in all the 3 cases. Clinicians should be aware of this entity because of diagnosis may be delayed in several months. |
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addiction,heroin addiction,heroin-neurologic complications with arachnoiditis brain biopsy cerebrospinal fluid,pressure increased delay in diagnosis fever fungal infection,CNS,treatment of headache hydrocephalus hypoglycorrhachia immunocompetent intravenous drug abuse meningeal biopsy meningitis meningitis,adults meningitis,basilar meningitis,candida meningitis,chronic meningitis,fungal meningitis,fungal-negative CSF culture meningitis,granulomatous meningitis,neutrophilic meningitis,neutrophilic,persistent meningitis,spinal fluid smear and culture of meningitis,spinal fluid smear and culture-negative skin,lesions in neurologic disorders treatment of neurologic disorder
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