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Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke NEJM 377:1022-1032,1006,1093, Saver, J.L.,et al, 2017 See this aricle in Pubmed Article Abstract Among adults who had had a cryptogenic ischemic stroke, closure of a PFO was associated with a lower rate of recurrent ischemic strokes than medical therapy alone during extended follow-up.

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