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Intravenous Thrombolysis in Unwitnessed Stroke Onset: MR WITNESS Trial Results Ann Neurol 83:980-993, Schwamm, L.H.,et al, 2018 See this aricle in Pubmed Article Abstract Intravenous thrombolysis within 4.5 hours of symptom discovery in patients with unwitnessed stroke selected by qDFM, who are beyond the recommended time windows is safe. A randomized trial testing efficacy using qDFM appears feasible and is warranted in patients without large vessel occlusions.

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