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A total of 106 patients (63 males and 43 females:mean age, 44 years; range, 18-83 years) were included. Most common symptoms were changes in mental status, fever, headache, and seizure. HSV PCR was positive in 69% of patients tested, while brain involvement was detected on MRI in 95%. Acyclovir was started mostly within five days of main symptom and continued for greater than or equal to 14 days. Case fatality rate was 8%, while 69% of patients recovered with sequelae. Favorable prognosis was observed in 73% of patients. Multivariate analysis identified the duration of disease before hospital admission (odds ratio (OR) = 1.24) and the extent of brain involvement on MRI at the time of admission (OR=37.22) as two independent risk factors associated with poor prognosis. |
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acyclovir
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atypical
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disability,neurological
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encephalitis,viral
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heralding manifestation
herpes simplex encephalitis
herpes simplex encephalitis,atypical
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hypoglycorrhachia
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pleocytosis of cerebrospinal fluid
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prognosis
renal failure
review article
seizure
temporal lobe,lesion,bilateral
treatment of neurologic disorder
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