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Cerebral aspergillosis is associated with a significant morbidity and mortality rate. The imaging data present different patterns and no full consensus exists on typical imaging characteristics of the cerebral lesions. We reviewed MRI findings in 21 patients with cerebral aspergillosis and correlated them to the immune status of the patients and to neuropathological findings when tissue was available. The lesions were characterized by their number, topography, and MRI signal. Dissemination to the brain resulted from direct spread from paranasal sinuses in 8 patients, 6 of them being immunocompetent. Hematogenous dissemination was observed in 13 patients, all were immunosuppressed. In this later group we identified a total of 329 parenchymal abscesses involving the whole brain with a predilection for the corticomedullary junction. More than half the patients had a corpus callosum lesion. Hemorrhagic lesions accounted for 13% and contrast enhancement was observed in 61% of the lesions. |
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abscess,intracerebral abscess,intracerebral,multiple abscess,intracranial-fungal aneurysm aneurysm,fusiform aneurysm,intracranial aspergillosis fungal infection,CNS immunocompetent immunosuppression mortality MRI,abnormal MRI,contrast enhanced MRI,gradient-echo MRI,lesion burden MRI,serial MRI,susceptibility weighted MRI,target sign neuropathology prognosis review article
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