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Cerebral aspergillosis is associated with a significant morbidity and mortality rate. The imaging data present different patterns and no full consensus exists on typical imaging characteristics of the cerebral lesions. We reviewed MRI findings in 21 patients with cerebral aspergillosis and correlated them to the immune status of the patients and to neuropathological findings when tissue was available. The lesions were characterized by their number, topography, and MRI signal. Dissemination to the brain resulted from direct spread from paranasal sinuses in 8 patients, 6 of them being immunocompetent. Hematogenous dissemination was observed in 13 patients, all were immunosuppressed. In this later group we identified a total of 329 parenchymal abscesses involving the whole brain with a predilection for the corticomedullary junction. More than half the patients had a corpus callosum lesion. Hemorrhagic lesions accounted for 13% and contrast enhancement was observed in 61% of the lesions. |
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abscess,intracerebral
abscess,intracerebral,multiple
abscess,intracranial-fungal
aneurysm
aneurysm,fusiform
aneurysm,intracranial
aspergillosis
fungal infection,CNS
immunocompetent
immunosuppression
mortality
MRI,abnormal
MRI,contrast enhanced
MRI,gradient-echo
MRI,lesion burden
MRI,serial
MRI,susceptibility weighted
MRI,target sign
neuropathology
prognosis
review article
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